Popular Weight Loss Injections; Ozempic, Zepbound, Semaglutide (GLP-1 receptor agonists) and Your Health: Managing Potential Side Effects and Nutrient Deficiencies

Thinking about weight loss injections like Ozempic, Zepbound, or Semaglutide? You’re not alone—these medications are becoming some of the most talked-about tools to help lose excess body weight and treat diabetes (particularly type 2 diabetes).

Ozempic (semaglutide), Zepbound (tirzepatide), and other GLP-1 receptor agonists are injectable prescription medicines primarily used to treat diabetes and, in some cases, to help adults with obesity lose excess body weight. These medications mimic the incretin hormone GLP-1 (glucagon-like peptide-1), which stimulates insulin secretion, inhibits glucagon release, and slows stomach emptying. While slowing digestion helps control blood sugar and promote satiety, it can sometimes lead to nutrient deficiencies or severe stomach problems if not monitored.

How Semaglutide Can Affect Nutrient Intake

Reduced Food Intake

These injections increase satiety, which means patients often eat less overall. While this is helpful for losing weight and managing calories, it can reduce intake of essential nutrients:

• Appetite Suppression: GLP-1 receptor agonists help patients lose weight by increasing feelings of fullness. This can also reduce the consumption of essential vitamins and minerals.

• Caloric Restriction: Those on semaglutide may follow a reduced calorie diet, which—if not carefully balanced—can contribute to weight-related medical problems or nutrient deficiencies.

Slowed Gastric Emptying

By slowing the passage of food from the stomach to the small intestine, nutrient absorption may change in rate and efficiency:

• Delayed Digestion: The slower passage of food can alter nutrient absorption over time.

• Nausea and Vomiting: Common side effects include nausea, vomiting, and abdominal pain, which can further reduce nutrient intake.

Gastrointestinal Symptoms

Chronic issues like diarrhea may occur with these injections and can lead to malabsorption, which can impact overall health. Regular micronutrient assessments are recommended to prevent deficiencies.

• Malabsorption: Chronic issues like diarrhea or severe stomach pain may impair absorption of fat-soluble vitamins (A, D, E, K), minerals, and proteins.

Specific Nutrient Deficiencies to Monitor

• Vitamin B12: Essential for energy, red blood cell formation, and neurological health. Deficiency may lead to unusual tiredness or fatigue.

• Iron: Reduced intake can cause anemia.

• Protein: Low protein intake can affect muscle mass and overall body function.

• Electrolytes: Diarrhea or vomiting may affect magnesium and potassium levels.

Bone Health: Nutrients like calcium and vitamin D are critical, especially since weight loss with semaglutide can impact bone mass over time.

Managing Nutrient Deficiencies

• Regular Monitoring: Blood tests every 3-6 months can detect deficiencies early.

• Dietary Counseling: Focus on nutrient-dense foods and consider supplements.

• Collaborative Care: Work with healthcare providers, dietitians, and nutritionists for holistic support.

• Customized Treatment Plans: Ensure micronutrient needs are met to maintain overall health while using GLP-1 receptor agonists.

Common Side Effects of Semaglutide

• Nausea, vomiting, diarrhea, constipation, abdominal pain, or severe stomach pain

• Risk of pancreatitis, gallbladder problems, or kidney injury

• Low blood sugar (especially with other diabetes medications)

• Injection site reactions (upper arm, stomach area)

Serious allergic reactions or trouble breathing should prompt immediate medical attention. Other symptoms requiring urgent care include fast heartbeat, slurred speech, or severe rash.

Guidelines for Injection and Dosing

• Administered under the skin (subcutaneously), usually in the stomach area, thigh, or upper arm.

• Follow a weekly injection schedule; for missed doses, contact your healthcare provider for instructions.

• Store at room temperature until use.

Combining Semaglutide with Lifestyle and Wellness Therapies

IV Hydration Therapy for Electrolytes and Nutrients

IV hydration helps manage nausea, vomiting, or diarrhea, replenishes electrolytes like magnesium and potassium, and supports nutrient balance, hydration, and overall health during treatment.

Vitamin Shots to Address Micronutrient Deficiencies

Vitamin injections, such as B12 shots, combat fatigue and weakness caused by reduced appetite or nutrient absorption. They can be customized for individual micronutrient needs, supporting energy and muscle maintenance.

Red Light Therapy for Skin Health and Recovery

Red light therapy promotes collagen and elastin production, improves blood flow, and accelerates cellular repair. This can help tighten loose skin after weight loss while supporting overall skin health.

Infrared Sauna Therapy to Support Weight Loss and Recovery

Infrared saunas complement injections by supporting metabolism, detoxification, stress reduction, and circulation.

• Enhanced Metabolism: Increases caloric burn and improves circulation, complementing appetite suppression and gastric emptying effects.

• Improved Exercise Recovery: Supports muscle recovery and reduces discomfort, helping maintain consistent workouts.

Body Composition Testing for Fat Loss and Muscle Retention

Tracking fat loss and lean mass helps your provider adjust your plan to maximize weight loss while minimizing muscle loss, ensuring safe, long-term results.

Health Risks and Considerations

• Thyroid tumors: Avoid if you have personal or family history of thyroid cancer, medullary thyroid carcinoma, or multiple endocrine neoplasia syndrome type 2.

• Chronic kidney disease / kidney failure: Use cautiously; monitor kidney problems.

• Cardiovascular disease: May reduce risk of cardiovascular death, but monitor for heart attack or fast heartbeat.

• Diabetic retinopathy: Report blurred vision or other eye issues promptly.

• Pregnancy / Breastfeeding: Avoid in unborn baby or breast milk exposure without guidance.

Semaglutide for Weight Loss: Effectiveness

• Clinical trials show an average of 10-15% weight loss over 68 weeks for semaglutide 2.4 mg weekly.

• Primarily targets excess weight (fat mass), with some reduction in lean mass.

• Combining therapy with resistance training, a reduced calorie meal plan, and lifestyle interventions improves long-term outcomes.

Conclusion

Semaglutide and other GLP-1 receptor agonists offer a promising tool to lose weight, treat diabetes, and improve overall health. Awareness of potential side effects, careful nutrient monitoring, and collaboration with healthcare professionals ensure safe, effective, and sustainable weight management.

Book an initial visit to discuss whether this medication is right for you and receive personalized support throughout your wellness journey.